BMS demonstrates superior efficac

The study authors explained that there is variability in results from previous studies, which demonstrated differences in both the extent and durability of blood pressure reduction and hypertension remission following BMS. Therefore, they conducted an extensive systematic review and meta-analysis to evaluate the comparative effectiveness of non-surgical treatment versus BMS in managing hypertension in obese individuals with this condition.

The researchers identified 29 RCTs for inclusion in the current meta-analysis and systematic review. The articles included in the review were published between 2004 and 2024. The majority of the studies were conducted in the USA (12 studies), followed by Australia (6 studies) and Brazil (5 studies). In total, this review analyzed data from 2,548 patients, with 1,249 patients in the surgical groups and 1,158 in the non-surgical groups.

Twenty-six RCTs were included in the analysis, comparing systolic blood pressure changes between surgical and non-surgical interventions. The heterogeneity was relatively high (I² = 66.7%). Patients in the surgical arms experienced a significantly greater reduction in SBP compared to those in the non-surgical arms (MD: -4.506 mmHg; 95% CI: -6.999 to -2.013; p=0.001). Sensitivity analyses using leave-one-out and fixed-effect methods also indicated significant differences in SBP changes between the surgical and non-surgical groups. However, sensitivity analysis with ten studies that had more than 50 patients in each arm did not show a significant difference between the interventions (MD: -2.939 mmHg; 95% CI: -7.199 to 1.321; p=0.15).